New publication on PET imaging
Quantitative PET imaging of PD-L1 expression in xenograft and syngeneic tumor models using a site-specifically labelled PD-L1 antibody
Despite remarkable clinical responses and prolonged survival across several cancers, not all patients benefit from PD-1/PD-L1 immune checkpoint blockade. Accordingly, assessment of tumor PD-L1 expression by immunohistochemistry (IHC) is increasingly applied to guide patient selection, therapeutic monitoring, and improve overall response rates. However, tissue-based methods are invasive and prone to sampling error. We therefore developed a PET radiotracer to specifically detect PD-L1 expression in a non-invasive manner, which could be of diagnostic and predictive value.
The imaging specificity of Zr-89 radiolabeled anti-PD-L1 monoclonal antibody (clone 6E11) was evaluated in a panel of non-small cell lung cancer xenograft models and in syngeneic models with different levels of PD-L1 expression. To evaluate the predictive value of 89Zr-DFO-6E11 PET imaging, CT26 tumor-bearing mice were subjected to external radiation therapy (XRT) in combination with PD-L1 blockade.
In the publication we demonstrate specific non-invasive imaging of tumor PD-L1 expression. Futhermore we show that PD-L1 expression can be modulated by external radiotherapy and 89Zr-DFO-6E11 PET is able to monitor these changes and predict the response to therapy in an immunocompetent tumor model. Please see full article to read more.
Poster presentation at the AACR annual meeting 2021
Minerva Imaging are happy to share the use of our intracranial breast […]Read story
Minerva Imaging is presenting at the AACR-NCI-EORTC 2019
Minerva Imaging is presenting at the AACR-NCI-EORTC Conference 2019Read story